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SPRAVATO®

Transform Your Life with SPRAVATO®

Developed by Janssen Pharmaceuticals, SPRAVATO® is an FDA-approved medication that has shown promising results in treating treatment-resistant depression. If you or a loved one have been living with depression and have not found relief with traditional antidepressant therapies, Spravato may be the solution you’ve been searching for. With its unique mechanism of action, SPRAVATO® has helped countless individuals reclaim their lives and find hope for a brighter future. Keep reading to learn more about this life-changing treatment.

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How Does SPRAVATO® Work?

A low dose of SPRAVATO® will be administered via intranasal spray. After five minutes another small dose will be administered. Your provider will monitor you for a two-hour waiting period. We encourage you to wear eyeshades, listen to relaxing music, and focus inward during this time.

Conditions Treated

  • Patient with MDD who have had an inadequate response to 2 or more oral Ads (Treatment-Resistant Depression)
  • Depressive symptoms in adults with MDD and acute suicidal ideation or behavior

Are You A Good Candidate?

If your answer is yes to any of the following, then you might be a good candidate for SPRAVATO® Treatment:

  • Diagnosis of Treatment Resistant Depression or MDD with acute suicidal ideations
  • Must currently be prescribed and taking an oral antidepressant (Spravato is for use in conjunction with oral AD)
  • Tried and failed at least 2 different antidepressants in your current depressive state

If you have experienced any of the following, SPRAVATO® might not be the right treatment for you:

  • Aneurysmal vascular disease
  • History of intracerebral hemorrhage
  • Hypersensitivity to esketamine, ketamine, or and related medications

What To Expect

  • Patient will self administer Spravato in office as a nasal spray (maybe a link to the administration guide through Spravato website?)
  • Monitored in office for at least 2 hours (we will obtain vitals as certain time points) – encourage to wear eyeshades, listen to relaxing music, and focus inward during this time.
  • Side effects: Typical side effects include minor sedation, nausea, or dissociation – provide a link to Spravato insert?)
  • Will need a driver to take you home

What Are The Side Effects of SPRAVATO®?

Typical side effects include minor sedation, nausea, or dissociation.

Does Insurance Cover SPRAVATO®?

We understand that navigating insurance coverage for SPRAVATO® can be a source of stress for our patients. At our office, we are committed to making this process as seamless as possible. While some insurance providers do cover SPRAVATO®, others may not. Rest assured that our team is actively working to determine which insurance providers cover SPRAVATO® and fighting to obtain answers for our patients. We believe that access to life-changing treatments like SPRAVATO® should not be hindered by insurance coverage, and we are dedicated to advocating for our patients every step of the way.

How Do I Get SPRAVATO®?

1.Contact us
2.New Patient Paperwork (password secure link for paperwork)
3.Prior authorization process
4.REMS enrollment
5.Treatment: 2x week for 4 weeks, 1x for 4 weeks, then maintenance every other week or weekly as needed for depressive symptoms (your individual treatment plan may vary depending on symptoms

Contact Us

Take time to thoroughly review the information and resources found on this website. If you feel like you or a loved one would benefit from SPRAVATO®, Contact Klarity to begin the process. In as little as a few days, you could be on your way to experience the relief you previously thought was impossible.

New Patient Paperwork

Upon contacting Klarity, Dr. Reed will call you to discuss your condition and answer any questions you may have. You will then be asked to fill out a few forms and sign a release, giving Klarity permission to contact your current mental healthcare provider. ​When the decision is made to proceed with treatment, your first infusions will be scheduled. Payment in advance is required. At this time, most insurances do not cover SPRAVATO® for depression.

Pre-Treatment Consultation (in-person or via TeleHealth – if necessary)

Treatment is initiated with 6 infusions given over a 2 week time period – typically following a Monday-Wednesday-Friday schedule (a different protocol will be set up for chronic pain patients). Upon completion of the 3rd infusion, an assessment will be performed to ensure you are responding and should continue with the therapy. Research has indicated an astounding 70% of treatment-resistant depression patients experience relief and functional improvement.

During this process, and throughout your care with Klarity, Dr. Reed will update and consult with your primary mental healthcare provider and you will continue to follow their guidance.

Insurance Approval Process

During your initial period of relief you may be able to make life changes that help manage depression symptoms when they return, although it is likely that ongoing maintenance infusions will be required to maintain the positive results. For most patients, follow-up infusions are necessary every 4-6 weeks after the initial infusions are completed.

REMS Enrollment (FDA-required Risk Evaluation and Mitigation Strategy)

During your initial period of relief you may be able to make life changes that help manage depression symptoms when they return, although it is likely that ongoing maintenance infusions will be required to maintain the positive results. For most patients, follow-up infusions are necessary every 4-6 weeks after the initial infusions are completed.

Begin SPRAVATO® Treatment

During your initial period of relief you may be able to make life changes that help manage depression symptoms when they return, although it is likely that ongoing maintenance infusions will be required to maintain the positive results. For most patients, follow-up infusions are necessary every 4-6 weeks after the initial infusions are completed.

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SPRAVATO® FAQs

SPRAVATO® is a prescription nasal spray used along with an oral antidepressant to treat adults with treatment-resistant depression (TRD).
SPRAVATO® works by restoring the balance of certain chemicals in the brain, including glutamate, which is thought to play a role in depression.
Yes, SPRAVATO® is a controlled substance because it contains the active ingredient esketamine, which has a potential for abuse and dependence.
SPRAVATO® is administered as a nasal spray in a healthcare provider’s office or clinic, under the supervision of a healthcare professional.
SPRAVATO® is usually administered twice a week for the first month and then once a week or every other week, depending on the patient’s response and the healthcare provider’s recommendation.
The most common side effects of SPRAVATO® include dissociation (feeling disconnected from reality), dizziness, nausea, sedation, spinning sensation, and feeling drunk. These side effects usually occur within 2 hours of administration and typically resolve within 1-2 hours.
Coverage for SPRAVATO® may vary depending on the patient’s insurance plan. It is recommended to check with the insurance provider or the healthcare provider’s office for more information on coverage and potential out-of-pocket costs.

SPRAVATO® is administered as a nasal spray. Your healthcare provider will instruct you on how to use it.

The dosing of SPRAVATO® varies depending on your specific condition and individual needs. Your healthcare provider will determine the appropriate dosing schedule for you.

Like all medications, SPRAVATO® can cause side effects. Some common side effects include dissociation (feeling detached from reality), dizziness, nausea, sedation, vertigo, decreased feeling or sensitivity, anxiety, lethargy, increased blood pressure, vomiting, feeling drunk, and feeling abnormal.
SPRAVATO® has the potential for abuse and dependence, similar to other drugs that affect the central nervous system. It is important to follow your healthcare provider’s instructions for use and not to exceed the prescribed dose.
It is not recommended to use SPRAVATO® during pregnancy or while breastfeeding. You should discuss any potential risks and benefits with your healthcare provider.
SPRAVATO® can cause drowsiness, dizziness, and dissociation. You should not drive or operate machinery until you know how SPRAVATO® affects you.
SPRAVATO® should be stored in a refrigerator between 2°C to 8°C (36°F to 46°F). It can be stored at room temperature for up to 1 month, but should be discarded if not used after that time.

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